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Margaret Pittman (

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1901-1995)

Biography

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Harvey Alter, M.D., is an NIH physician-scientist and virologist best known for his work that led to the discovery of hepatitis B and C. For the latter work, on hepatitis C, he was awarded the 2000 Albert Lasker Award for Clinical Medical Research and the 2020 Nobel Prize in Physiology or Medicine. Alter came to the NIH in 1961 as a Clinical Associate. He left in 1964 to pursue residency and fellowship opportunities but returned to the NIH 1969 as an investigator in the Clinical Center’s Department of Transfusion Medicine. He became Chief of the Clinical Studies Section and, in 1987, Associate Director of Research in the Department of Transfusion Medicine.

Alter dedicated his career to studies intended to ensure the safety of blood transfusions. In 1963, with Baruch Blumberg, he co-discovered the Australia antigen, the surface antigen of the hepatitis B virus (HBV), which led to isolating HBV and ultimately creating a vaccine to prevent infection. In the 1970s, while analyzing blood from NIH patients and blood donors, Alter discovered what he then called non-A, non-B hepatitis. This led to the discovery of the hepatitis C virus by 1988 as well as screening tests that reduced the risk of contracting hepatitis via a blood transfusion to nearly zero. Later in his career, Alter worked on a DNA approach to vaccinesPittman came by medicine early, helping her father, a country doctor, in his rural Arkansas practice. She attended the University of Chicago with money she had saved from teaching and received her Ph.D. in 1928. Following positions at the Rockefeller Insititute and the New York State Department of Health, she came to the NIH in 1936 and began working with Dr. Sara Braham, who had taught her at the Unviersity of Chicago. She is recognized for her work on an improved and standardized pertussis (whooping cough) vaccine. At the Rockefeller Institute of Medical Research, Pittman developed studies on strains of H. influenzae isolated from infected patients. At the National Institute of Health, she became the first woman to hold the position of laboratory chief, heading the Laboratory of Bacterial Products, Division of Biologics and Standards, from 1957 to 1971. Pittman isolated the influenza strain responsible for most childhood meningitis, helped identify the cause of epidemic conjunctivitis, and made key observations that led to the development of a Salmonella vaccine. In 1970 Margaret Pittman was recognized with the Federal Women's Award, and she served as president of the Society of American Bacteriologists and of the Washington Academy of Sciences. Although Pittman “retired” in 1971, she kept working at NIH as a guest until 1993. The Margaret Pittman Lectureship, created in 1994, honors Pittman for her exceptional research achievements at the National Institutes of Health.


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Harvey Alter sitting at a table, writing in a notebookImage Removed


Resources 

Oral Histories

Non-Journal Sources

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Available Files

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Dr. Harvey Alter poses with the Lasker Award in 2000.Image Removed

Dr. Harvey Alter with Lasker Award in 2000.

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Photo credit: Bill Branson, courtesy of the Office of NIH History and Stetten Museum

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Harvey Alter standing in NIH Clinical Center Department of Transfusion MedicineImage Removed

Dr. Harvey Alter in NIH Clinical Center Department of Transfusion Medicine, 2004.

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Photo credit: Rhoda Baer, courtesy of the Office of NIH History and Stetten Museum

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Harvey Alter sitting at a table, writing in a notebookImage Removed

Dr. Harvey Alter at his desk in the NIH Clinical Center Department of Transfusion Medicine, 2000.

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