What is
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Aging?
In the late 1970s, Earl gradually shifted the focus of his research from the regulation of enzyme activities to that of protein turnover—the process by which damaged or inactivated proteins are removed from cells. How do the cells recognize malfunctioning enzymes? What are the signs of those "troubled" enzymes? In short, what governs the regulation of protein turnover? After studying the activity of normal or "healthy" enzymes for decades, Earl sought to understand how cells can selectively degrade certain proteins which are no longer needed because of changes in their environment. This problem led him to investigate the characteristics of "not-so-healthy" enzymes and their ultimate degradation into smaller pieces, such as amino acids. It was largely an unexplored area of research in biochemistry.
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