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The AMINCO-Bowman Spectro-photofluorometer

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Dr. Bernard B. "Steve" Brodie was an internationally renowned pharmacologist whose groundbreaking work at Goldwater and NIH-including his involvement in the development of Tylenol-earned him many honors. Dr. Brodie attended McGill University in Montreal and then studied organic chemistry at New York University. He came to Goldwater Memorial Hospital to work with Dr. James Shannon's antimalarial group during World War II. His important publications in the 1940s helped lay the groundwork for the future study of drug metabolism.
As head of the Laboratory for Clinical Pharmacology at NIH after the war, Dr. Brodie worked with and trained a group of scientists who would become the leaders in the science of drug metabolism. Their work was accompanied by increased research into instrumentation and technology, including the spectrophotofluorometer. Dr. Brodie won the Lasker Award, often considered the American Nobel Prize, in 1967. The award cited his "extraordinary contributions to biochemical pharmacology."

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Brodie in officeImage Modified
Bernard "Steve" Brodie

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Dr. Sidney Udenfriend, a member of the Goldwater antimalarial group, subsequently worked with Dr. Bowman at the National Heart Institute (NHI) and analyzed and catalogued substances using the spectrophotofluorometer (SPF). Udenfriend had earned his master's degree at New York University (NYU) when he joined the Goldwater group in 1942. He and Dr. Brodie developed the special test with the photofluorometer to screen and test antimalarial drugs during World War II. After the war, Udenfriend returned to graduate school at NYU to finish his doctorate. Dr. Udenfriend came to work at the NHI in 1950 at Dr. Shannon's invitation, following a postdoctoral fellowship at Washington University in St. Louis. At NHI he helped his colleague Robert Bowman develop the SPF.

Dr. Udenfriend left NIH for private industry in 1967 to become the founding director of the Roche Institute of Molecular Biology (RIMB), a position he held until1983. Formerly located in Nutley, New Jersey, RIMB was originally staffed by many of Udenfriend's former colleagues from Dr. Brodie's lab at NIH. When RIMB closed its Nutley laboratories in 1995, Dr. Udenfriend, who still maintained an active lab there until the closure, called the institute "the envy of scientists around the world, a camelot of the biological sciences."

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Photograph of Dr. Sidney Udenfriend
Sidney Udenfriend

Article about spectrophotofluorometerImage Modified
In 1995 Dr. Sidney Udenfriend wrote a history of the SPF, "Development of the Spectrophotofluorometer and its Commercialization."

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