In 1925, Drs. Roscoe Spencer and Ralph Parker described their method for creating RMSF vaccine. The method would become more streamlined and automated after they moved into the Building One laboratory in 1928 and got better space and equipment than the Canyon Creek Schoolhouse laboratory could provide. These photos include some taken at Building One after the laboratory moved from the schoolhouse.
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The recipe for RMSF vaccine:
Because you use adult ticks, you have to start when the ticks are young the spring before to create a vaccine for the next spring.
1. Lab-reared adult ticks without RMSF are used. Feed female ticks to engorgement on rabbits and mate them.
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Image: Office of NIH History and Stetten Museum, 1478
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22. Put the females put in separate pill boxes, give the box a lot number, and place the box over moist sand so they can lay eggs.
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Image: Office of NIH History and Stetten Museum, 1487-1
