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Curiosity & Collaboration: The Work of Michael Potter (1924–2013)

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Mike Potter and Fritz Melchers of the Basel Institute for Immunology (below) organized annual Mechanisms in B Cell Neoplasia workshops that were held from 1983-1999 either at NIH or in Basel. The workshops compared normal B lymphocytes and plasma cells with their malignant counterparts, B cell leukemias, lymphomas, plasmacytomas and multiple myelomas. They searched for genetic, molecular, cellular and physiological differences between normal and malignant cells — differences that might contribute and, hence, explain the changes from normalcy to malignancy. It was hoped that the identification of molecular genetic alterations in tumors might offer targets for intervention to reverse and prevent tumor development.

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NIH Stetten Museum

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Courtesy of Dr. Beverly Mock, NCI


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These drawings by Phyllis Saroff illustrate a collection of papers from a 1985 workshop focused on the genetic diversity of “wild mice” (natural living house mice) and their use in research. The workshop was held because it had become apparent as genetic research progressed, that inbred strains of mice offered only a limited window into the genetic diversity in mice. Edited by Potter, Joseph Nadeau, and Michael Cancro, the book amazed reviewers by cataloging available stocks of mice and their sources. Depicted are M. pahari, M. spretus, M. minutoides, M. cervicolor, M. caroli, M. castaneus, and M. saxicola from Potter’s NCI colony of mice. More information can be found on the   Potter's Books Artifact page. (TODO: Link)

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From the permanent collection of the NIH Stetten Museum. Courtesy of Dr. Beverly Mock, NCI

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