Testing for
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Bacterial Endotoxins
Testing for endotoxins (a toxin present in a bacteria cell that is released when the cell disintegrates) in injectable biologics was revolutionized in Building 29A by Drs. Edward Seligmann and H. Donald Hochstein. Endotoxins are part of the outer membrane of the cell wall of Gram-negative bacteria and had been discovered to be the cause of fevers in some patients receiving injections.
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This testing was conducted in the Pyrogens Section of the Division of Biologics Standards (DBS) Laboratory of Control Activities, which was located in Building 29, fourth floor from 1960 to 1967, then moved to Building 29A, first floor when the annex building opened in 1967.
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