Building 29A had a different floor plan and design from Building 29 and most other lab buildings at NIH. Instead of a central corridor, there was an exterior corridor around the entire perimeter of the building and then two smaller cross corridors. Labs faced the interior of the building and were shielded from light, heat, and noise from outdoors. A utility core behind each hallway allowed for this configuration and brought electric, plumbing, gas, etc. to the labs. Air intake towers, located in the median of the parking area in front of the building, provided clean air for the mechanical system, while a high velocity exhaust air system was placed on the roof to ensure dilution and dispersion of laboratory and vivarium exhaust air.