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Matching Immunoglobulins to their Antigens
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Potter worked with Rose Lieberman on the third question he had scrawled: What is the genetic basis of antibody diversity? They found three genetic “types” in each immunoglobulin. “Isotype” genes on the constant regions determine the class and sub-class of the immunoglobulin. “Allotypes” distinguish the constant region sequences that are unique to the mouse strain. And “idiotypes” in the variable region reflect genetic sequences associated with an immunoglobulin’s specificity; sometimes immunoglobulins bind to the same antigen, but their idiotype genes are different.
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