Page Comparison - Potter Antibodies (v.26 vs v.27)

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The illustration, on the right, shows the basic structure of immunoglobulins. Molecules in the heavy chains weigh more than those in the light chains. The amino acids in the constant regions do not change, while those in the variable region usually do change. Potter asked how this structure affects how immunoglobulins protect the body.

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Graphic depicting antigen binding sites

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Based on an illustration from the University of Arizona

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In their Building 8 laboratory, Potter and Elizabeth Mushinski began screening the immunoglobulins produced by plasma cell tumors against all types of antigens to match antibody to antigen. In 1968, they identified the MOPC315 immunoglobulin and its antigen, pneumococcal C polysaccharide, which is a component of the bacteria that causes pneumonia.

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Michael P. Cancro, Ph.D., University of Pennsylvania

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This 1976 photograph shows how Potter augmented his glasses with the addition of magnifying lenses that allowed him to see small details. It is perhaps the best visual metaphor for his careful and precise research.

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Michael P. Cancro, Ph.D., University of Pennsylvania

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Old Version 26

New Version 27

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Office of NIH History and Stetten Museum