From 1943 until her retirement in 1971, Dr. Margaret Pittman worked to assess the efficacy of and establish national and international standards for the production of the typhoid vaccine. Dr. John B. Robbins and colleagues also worked on typhoid vaccines, promoting the assessment of the Vi capsular polysaccharide for protection of humans against typhoid.

There are 2 vaccines licensed for use in the US currently, for people who are traveling to at-risk areas: Ty21a which is an oral capsule, and Vi capsular polysaccharide (ViCPS) which is injected.