In 1934, the first human blood product licenses were issued to two pharmaceutical houses for human immune globulin prepared by ammonium sulfate precipitation. After the development of cold ethanol fractionation procedures, additional new products were licensed including normal human plasma (1940), normal serum albumin (1941), and immune serum globulin (1943). The first license for interstate shipment of whole blood, and the first blood bank license was issued to the Philadelphia Blood Bank in 1946. Each of these products was licensed under Section 351 of the Public Health Services Act and was considered analogous to therapeutic serum.
Becton, Dickinson & Co. Yale Luer-Lok 100 cc Syringe from between 1953 and 1970. In 1934, BD introduced the BD Yale Luer-Lok™ Syringe, designed and patented by Fairleigh S. Dickinson, Sr. It provided a simple, secure method of attaching and removing a needle to and from a syringe. Today, Luer-Lok connectors are the standard for syringes in the United States.
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Blood products can include blood, red blood cells, fresh/frozen plasma, platelets, plasma derivatives, albumen, immune globulins, clotting factor concentrates, things that are made by recombinant DNA technology, reagents that test for infectious disease or are used to type the blood, and even the blood bank software used to keep track of the donations. All of these were regulated by the NIH Division Biologics Standards (DBS) and later the Center for Biologics Evaluation and Research (CBER) when they were transferred to the Food and Drug Administration (FDA).
Becton, Dickinson & Co. Cornwall 2 cc Syringe dating from 1954 to 1970. The patent was filed June 12, 1948, and granted to Henry G. Molinari on July 27, 1954. The patent was assigned to Becton, Dickinson & Co. From the patent claims: "...the assembly should include not alone a glass barrel or cylinder, but also a piston or plunger rod of glass slidable within that barrel. By movement of the latter not alone may medicament be expelled from the barrel for purposes of injection, but also that medicament may be drawn into the cylinder to charge the syringe with a suitable quantity of desired liquid....the barrel is usable with only the particular plunger selected for same....it is a primary object of the invention...[that] these assemblies will have their parts interchangeable so that it will be unnecessary to, for example, identify the barrel and plunger by identical serial numbers." Note that such serial numbers ARE on this syringe.
