Dr. Ruth L. Kirschstein (1926–2009)
"I have felt, and still feel, that there is no more worthy endeavor than to serve the country, its people, and the science which has given me so much joy.”
—Dr. Ruth L. Kirschstein
Dr. Ruth Kirschstein was the first woman at NIH to head an institute (the National Institute of General Medical Sciences [NIGMS]) and the first woman to serve as Director of the NIH (in 1993 and again in 2000).
Ruth Kirschstein was born in Brooklyn, New York in 1926. Her father’s family immigrated from a village near the borders of Poland and Russia when he was eight years old. Her father grew up to become a chemist who inspired in her an interest in science and a love of music. Her mother was a public school teacher. Ruth received her B.A. magna cum laude from Long Island University in 1947 and her M.D. from Tulane University School of Medicine in 1951.
Dr. Kirschstein came to the NIH in 1955 with her husband, pathologist Dr. Al Rabson. She researched cancer viruses early in her career and then live-virus vaccines: polio vaccine, measles vaccine, and rubella vaccine. In 1955, the year following a field trial that showed the Salk inactivated (killed) polio vaccine to be safe and effective, DBS licensed several firms to produce the vaccine. One, Cutter Laboratories, accidentally released vaccine that retained live polio virus, resulting in 260 paralytic cases of the disease, a disaster that caused panic among parents and scientists alike.
In the following years, Dr. Kirschstein’s polio investigations paved the way for safer vaccines, both the killed vaccine and live, attenuated oral polio vaccine. She and her colleagues shed light on the pathogenesis of the polio virus and developed a standardized test involving precise, experimental inoculation of vaccine matter. It served as the basis for the testing DBS conducted on every lot of polio vaccine produced and the laboratory instructed vaccine producers and others that needed to know the procedure from around the world.
An authority on infectious neuropathology of monkeys, she received the Department of Health, Education, and Welfare (DHEW) Superior Service Award in 1971 for her contributions in developing monkey safety tests to live viral vaccines and for research on viral oncogenesis.
Dr. Kirschstein became chief of the Division of Biologics Standards (DBS) Laboratory of Pathology in 1961. She was promoted to assistant director of the Division of Biologics Standards in 1972. When DBS moved administratively to the Food and Drug Administration (FDA), Dr. Kirschstein became the deputy director of what then became called the FDA Bureau of Biologics.
She was the first woman at NIH to head a NIH Institute. She was the Director of the National Institute of General Medical Sciences (NIGMS) from 1974 until 1993. In 1993 she became acting Director of NIH, the first female to fill this role. In 2000, she again became acting Director.
Dr. Kirschstein worked in Building 29, Rooms 209, 512, and 516 during her time with Biologics.
Dr. Samuel Baron (left), Dr. Ruth Kirschstein (center), and unidentified man (right). Always There publication.
Dr. Ruth Kirschstein National Library of Medicine
Dr. Kirschstein's Own Reflections
- NIH Oral History Interviews:
- Interview date: September 21, 1988
- Interview date: October 29, 1998
- Interview date: November 10, 1998
- Interview date: February 2, 1999
- Interview date: March 17, 1999
- Interview date: April 15, 1999
- Interview date: June 10, 1999
- Interview date: August 16, 1999
- Interview date: January 17, 2008
Publications
- “Lack of significant oncogenicity of biological products in hamsters” by Claire B. Cox, John Landon, Marion G. Valerio, Amos Palmer, Ruth L. Kirschstein and Stanley H. Singer in Applied Microbiology (1972). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC380416/.
- “The Safety Test for Poliomyelitis Vaccine. III. Comparative Sensitivity of Rhesus and Vervet Monkey to Poliovirus” by Gerald L. Van Hoosier, Jr., Samuel Baron, Ruth L. Kirschstein, and Francis R. Abinanti in the American Journal of Epidemiology (1961). https://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1023.254&rep=rep1&type=pdf.
- “A Call to Action” by Ruth L. Kirschstein and John Ruffin. In Public Health Report (2001). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1497377/pdf/12196609.pdf.
- Always There: The Remarkable Life of Ruth Lillian Kirschstein, M.D., 2011 (PDF, 9,243 kB) https://www.nih.gov/sites/default/files/about-nih/Always_There_0.pdf
Image Gallery
Geraldine P. Woods Award that Dr. Kirschstein received in 2002 at the Annual Biomedical Research Conference for Minority Students. She was praised for her leadership, dedication, and commitment to the research training of minorities while at the head of NIGMS and NIH.
A photo of Dr. Kirschstein looking through a bacteria colony counter