John Finlayson, Ph.D. (1930-2020)

John Finlayson grew up in New Jersey, Delaware, Virginia, and Ohio. He completed high school in 1945 at the age of 15. He went to college in Ohio and was pre-med. Instead of going to medical school, he completed a masters (1955) and Ph.D. (1957) in Biochemistry at University of Wisconsin-Madison. He was able to do draft deferment for another year to do a post-doctoral fellowship at the Institute of Radiophysics in Sweden.

Dr. Finlayson came back to US in the fall of 1958 and got a commission in the Public Health Service (PHS). He was assigned to the Laboratory of Blood and Blood Products in the National Institutes of Health (NIH) Division of Biologics Standards (DBS). He did his two years of service there. After 2.5 years he went into inactive reserve for the PHS and then worked in the same laboratory role, but as a civil servant now. From that point on he never left biologics. He was there for the administrative transition from the NIH to the Food and Drug Administration (FDA) in 1972. He worked in the Coagulation Section of the Laboratory of Blood and Blood Products when they were still under the NIH.

Dr. Finlayson worked on plasma derivatives most of his career, especially as related to hemophilia, a medical condition where the body can’t clot properly, sometimes causing severe bleeding, and Factor VIII, an essential blood-clotting protein, sometimes called anti-hemophilic factor (not licensed until 1966), derivatives.

a man and woman scientist stand in a lab wearing white lab coats, looking at the camera smiling

Dr. John Finlayson and Mimi Reyes in 1963 in a lab on the first floor of Building 29.

Lab equipment at the NIH 

Dr. John Finlayson's DEAE cellulose column. The column of DEAE cellulose column in the back was synthesized by Dr. Finlayson. The far bottle holds water and acts a counterweight to hold the base of the rod. The string handing down is a plumbline to keep the column straight. Sigma pump (black piece) or Sigma motor pump with housing on the top. The housing had small steel fingers hooked to a camshaft for sigmoid motion (a sin curve). The round-bottom flask has tubing leading to a pump to column and to Erlenmeyer flask through a rubber stopper. Photo taken inside cold room, Bldg. 8. Reset in Building 29 after the move in 1960. Buddy Kleer was the refrigerator technician to handle the move. Photos from John Finlayson’s Collection at Office of NIH History & Stetten Museum.
By 1997 he became the Assistant Director for Science at the FDA’s Center for Biologics Evaluation and Research (CBER), the ultimate successor to DBS. He retired in 2004 but continued to volunteer part-time at the FDA through 2014. He spent his entire 56-year career on the NIH campus, the first two years in Building 8, and then in Building 29. He passed away in 2020.

Dr. Finlayson worked in Building 29, first floor when his lab was part of the NIH. After the transition to the FDA, the Laboratory of Blood and Blood Products moved to the second and third floors of Building 29.


Oral History

Publications:

  • “Comparison of Human Plasma Fibrinogen Subfractions and Early Plasmic Fibrinogen Derivatives” by Michael W. Mosesson, Dennis K. Galanakis, and John S. Finlayson in the Journal of Biological Chemistry (1974). https://www.jbc.org/article/S0021-9258(19)42469-1/pdf.
  • “Effects of Long-Term Storage on Human Serum Albumin. I. Chromatographic and Ultracentrifugal Aspects” by John S. Finlayson, Richard T. Suchinsky, and Ann L. Dayton in the Journal of Critical Investigation (1960). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC441908/.
  • “Effects of Long-Term Storage on Human Serum Albumin. II. Follow-Up of Chromatographically and Ultracentrifugally Detectable Changes” by John S. Finlayson in the Journal of Critical Investigation (1965). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC292637/.