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This chromatography column from Pharmacia Fine Chemicals is one kind used in Anfinsen’s laboratory for affinity chromatography, a method that he began using in the 1960s to purify samples of the protein Staphylococcal nuclease, which enabled him to pinpoint the exact positions of the 149 individual amino acid units and their peptide bonds.

Other types of chromatography separate molecules based on size, differences in chemical or physical interactions, or strength of their ionic interactions. In affinity chromatography, a molecule called a “ligand” that binds to a specific receptor, is anchored to solid support. When a solution is passed over it, the ligand binds to the specific molecule that has an “affinity,” or natural bond, with it. After the other components of the solution are washed away, the now purified molecule is stripped from its support.

Chromatography Column Artifacts page

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Chromatography Column

Credit
From the permanent collection of the NIH Stetten Museum, courtesy of Dr. Christian Anfinsen

The Molecular Basis of Evolution

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Key to Building 3 Directory Box, 1938

Donated by Steve Griffin, Accession 04.0008.002

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Building 3 was one of the original laboratory buildings on the NIH’s Bethesda, Maryland campus, opening in 1938, to hold the Public Health Methods and Animal Unit. This key opened the Building 3 directory box, which listed the impressive array of scientists who worked in its laboratories, including five future Nobel laureates, three future NIH directors, a pharmaceutical company president, and 15 scientists who were inducted into the National Academy of Sciences

Learn more about the scientists in Building 3.

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The Molecular Basis of Evolution

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The Molecular Basis of Evolution

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The Molecular Basis of Evolution

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The Molecular Basis of Evolution

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The Molecular Basis of Evolution

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Key

The Molecular Basis of Evolution

Key to Building 3 Directory Box, 1938

The Molecular Basis of Evolution

The Molecular Basis of Evolution

The Molecular Basis of Evolution

The Molecular Basis of Evolution

The Molecular Basis of Evolution

Office of NIH History and Stetten Museum