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Potter now had the mice that would grow plasma cell tumors, but implanting plastic to induce the tumors was not ideal. Potter began working with Dr. Rose Lieberman from the National Institute of Allergy and Infectious Diseases, who had found that mice injected Freund’s adjuvant, made with mineral oil and antigens, produced large quantities of immunoglobulins. Potter and Lieberman struck a deal: he would do the pathology studies, if she would inject his BALB/c mice with Freund’s adjuvant.
But which component in the Freund’s adjuvant caused the plasma cell tumors? By 1962, Potter and Charlotte Robertson Boyce had tested each component of the adjuvant and found that mineral oil alone could induce transplantable plasma cell tumors.
Read Potter and Boyce’s paper “Development of Plasma-Cell Neoplasms in BALB/c Mice After Intraperitoneal Injection of Paraffin-Oil Adjuvant, Heat-Killed Staphylococcus Mixtures,” Journal of the National Cancer Institute, 25(4), October 1960, pp. 847-861.
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Donated by Dr. Beverly Mock |
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Donated by Dr. Beverly Mock |