1902 Biologics Control Act image from 1968 Murray publication. The Biologics Controls Act, or Virus Toxin Act, was passed in 1902 after 13 children died in St. Louis from tetanus, which had contaminated the diphtheria antitoxin they had received in 1901.
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1968 publication "The Division of Biologics Standards" (Public Health Service Publication No. 1744) by Dr. Roderick Murray
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Guinea pig image from 1968 Murray publication. In the 1960s, DBS was conducting approximately 35,000 control tests annually on samples of manufacturers’ products. Some 180,000 mice, 3,500 rabbits, 2,000 monkeys, and 8,600 guinea pigs were used annually for control tests.
