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They developed a new calibrated test, Limulus amebocyte lysate (LAL), for pyrogens (fever-causing endotoxins) using horseshoe crab blood instead of rabbits’ ears. LAL became the standard worldwide test for bacterial endotoxins.
Dr. Seligmann and Mr. William H. Berkeley also developed a patented direct contact tray assembly for freeze-drying biologics.
When DBS was transferred administratively to the Food and Drug Administration (FDA), LCA became known as the Division of Product Quality Control
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Dr. Edward B. Seligmann (right) and William H. Berkeley demonstrate use of their recently patented freeze-drying tray. |
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