his research studying how the hormone epinephrine
signals cells to release more sugar into the blood so that an organism
can respond to stress. He discovered that epinephrine works by stimulating
another chemical messenger to begin the sugar-releasing process
in the cell. He called this intermediary the "second messenger."
For more information about the second messenger, see the section
in this exhibit "Rodbell's
Inspiration: Sutherland's Second Messenger."
Earl Sutherland was born in Burlingame, Kansas on November 19, 1915.
He received his M.S. from Washington University, School of Medicine
in St. Louis in 1942, where he became a well-known teacher and researcher
in the areas of pharmacology and biochemistry. He later was a professor
and department director at the Western Reserve University, School
of Medicine in Cleveland, Ohio and Vanderbilt University, School
of Medicine in Nashville, Tennessee. He served on the National Institutes
of Health Pharmacology Training Committee, and Arthritis and Metabolic
Disease Program Committee. Sutherland's impact was widely felt,
with many Nobel laureates having either trained under his direction
or with mentors who had. For more information about Sutherland and
his work, see www.nobel.se/medicine/laureates/1971.
The Nobel Foundation