their separate laboratories, Guillemin and Schally investigated how
the brain controls the hormone-producing
glands. During the 1950s, they were able to extract substances which
direct the release of hormones from the pituitary,
thyroid, and gonad glands from the part of the brain called the hypothalmus.
Not until 1969, however, was either laboratory able to isolate and
purify one of those substances, Thyroid Releasing Factor (TRF). TRF
released Thyroid Stimulating Hormone (TSH). This discovery opened
up new avenues of research into how the brain and hormones work. For
more information about Guillemin and Schally's work, see www.nobel.se/medicine/laureates/1977/press.html.
"I always hoped that somehow I could one day work in a laboratory."
Roger C. L. Guillemin, Les Prix Nobel, 1977.
C. L. Guillemin was born in France on January 11, 1924 and studied
at the School of Medicine in Dijon, graduating in 1949. He moved to
Canada and studied at the University of Montreal. Later he taught
at Baylor University College of Medicine in Houston, Texas and became
interested in how the pituitary gland was controlled. He established
the Laboratories for Neuroendocrinology at the Salk Institute in San
Diego. Guillemin also served on several National Institutes of Health
advisory groups over the years. For more information about Guillemin,
"...I was encouraged that they and other
astute scientists had confidence in our work and the foresight to
appreciate the possible scientific and medical importance of hypothalamic
hormones." Andrew V. Schally, Les Prix Nobel, 1977.
Schally was born in Poland, November 30, 1926 and grew up in Nazi-occupied
Eastern Europe. In 1945, he moved to Scotland to study chemistry,
and then worked at the National Institute of Medical Research in
London. In 1952, he moved to McGill University in Montreal, Canada,
until 1957, when he went to Baylor University College of Medicine
in Houston, Texas, where he met Roger C. L. Guillemin. He later
had his own laboratory at Tulane University in New Orleans. An interest
in infertility problems and population control spurred him to investigate
the role of hormones in the brain. For more information about Schally,
The Nobel Foundation